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As evidence-of-principle that manipulation of Stage I metabolism would alter the in vivo effects of the SCBs, hypothermic effects of 3 mg/kg JWH-018 or 5F-AB-PINACA ended up determined using radiotelemetry during the presence or absence of the worldwide CYP450 inhibitor one-ABT in mice (Allspice, which acquired its name since it smells like the com